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1.
Sci Data ; 10(1): 374, 2023 Jun 08.
Article in English | MEDLINE | ID: covidwho-20237750

ABSTRACT

With the urgent need to implement the EU countries pledges and to monitor the effectiveness of Green Deal plan, Monitoring Reporting and Verification tools are needed to track how emissions are changing for all the sectors. Current official inventories only provide annual estimates of national CO2 emissions with a lag of 1+ year which do not capture the variations of emissions due to recent shocks including COVID lockdowns and economic rebounds, war in Ukraine. Here we present a near-real-time country-level dataset of daily fossil fuel and cement emissions from January 2019 through December 2021 for 27 EU countries and UK, which called Carbon Monitor Europe. The data are calculated separately for six sectors: power, industry, ground transportation, domestic aviation, international aviation and residential. Daily CO2 emissions are estimated from a large set of activity data compiled from different sources. The goal of this dataset is to improve the timeliness and temporal resolution of emissions for European countries, to inform the public and decision makers about current emissions changes in Europe.

2.
Sci Data ; 10(1): 217, 2023 04 17.
Article in English | MEDLINE | ID: covidwho-2306602

ABSTRACT

We constructed a frequently updated, near-real-time global power generation dataset: CarbonMonitor-Power since January, 2016 at national levels with near-global coverage and hourly-to-daily time resolution. The data presented here are collected from 37 countries across all continents for eight source groups, including three types of fossil sources (coal, gas, and oil), nuclear energy and four groups of renewable energy sources (solar energy, wind energy, hydro energy and other renewables including biomass, geothermal, etc.). The global near-real-time power dataset shows the dynamics of the global power system, including its hourly, daily, weekly and seasonal patterns as influenced by daily periodical activities, weekends, seasonal cycles, regular and irregular events (i.e., holidays) and extreme events (i.e., the COVID-19 pandemic). The CarbonMonitor-Power dataset reveals that the COVID-19 pandemic caused strong disruptions in some countries (i.e., China and India), leading to a temporary or long-lasting shift to low carbon intensity, while it had only little impact in some other countries (i.e., Australia). This dataset offers a large range of opportunities for power-related scientific research and policy-making.

3.
World J Gastroenterol ; 28(48): 6811-6826, 2022 Dec 28.
Article in English | MEDLINE | ID: covidwho-2201059

ABSTRACT

The global coronavirus disease 2019 (COVID-19) has become one of the biggest threats to the world since 2019. The respiratory and gastrointestinal tracts are the main targets for severe acute respiratory syndrome coronavirus 2 infection for they highly express angiotensin-converting enzyme-2 and transmembrane protease serine 2. In patients suffering from COVID-19, gastrointestinal symptoms have ranged from 12% to 61%. Anorexia, nausea and/or vomiting, diarrhea, and abdominal pain are considered to be the main gastrointestinal symptoms of COVID-19. It has been reported that the direct damage of intestinal mucosal epithelial cells, malnutrition, and intestinal flora disorders are involved in COVID-19. However, the underlying mechanisms remain unclear. Thus, in this study, we reviewed and discussed the correlated mechanisms that cause gastrointestinal symptoms in order to help to develop the treatment strategy and build an appropriate guideline for medical workers.


Subject(s)
COVID-19 , Gastrointestinal Diseases , Humans , COVID-19/complications , Gastrointestinal Diseases/therapy , Gastrointestinal Diseases/virology , Vomiting/therapy , Vomiting/virology
4.
J Med Virol ; 94(12): 5746-5757, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1976742

ABSTRACT

We evaluated and compared humoral immune responses after inactivated coronavirus disease 2019 (COVID-19) vaccination among naïve individuals, asymptomatically infected individuals, and recovered patients with varying severity. In this multicenter, prospective cohort study, blood samples from 666 participants were collected before and after 2 doses of inactivated COVID-19 vaccination. Among 392 severe acute respiratory syndrome coronavirus 2-naïve individuals, the seroconversion rate increased significantly from 51.8% (median antispike protein pan-immunoglobulins [S-Igs] titer: 0.8 U/ml) after the first dose to 96% (median S-Igs titer: 79.5 U/ml) after the second dose. Thirty-two percent of naïve individuals had detectable neutralizing antibodies (NAbs) against the original strain but all of them lost neutralizing activity against the Omicron variant. In 274 individuals with natural infection, humoral immunity was significantly improved after a single vaccine dose, with median S-Igs titers of 596.7, 1176, 1086.5, and 1828 U/ml for asymptomatic infections, mild cases, moderate cases, and severe/critical cases, respectively. NAb titers also improved significantly. However, the second dose did not substantially increase antibody levels. Although a booster dose is needed for those without infection, our findings indicate that recovered patients should receive only a single dose of the vaccine, regardless of the clinical severity, until there is sufficient evidence to confirm the benefits of a second dose.


Subject(s)
COVID-19 , Viral Vaccines , Antibodies, Neutralizing , Antibodies, Viral , COVID-19/prevention & control , COVID-19 Vaccines , Humans , Prospective Studies , SARS-CoV-2 , Vaccination , Vaccines, Inactivated
5.
Environmental Research Letters ; 17(3):031001, 2022.
Article in English | ProQuest Central | ID: covidwho-1746980

ABSTRACT

Fossil CO2 emissions in 2021 grew an estimated 4.2% (3.5%–4.8%) to 36.2 billion metric tons compared with 2020, pushing global emissions back close to 2019 levels (36.7 Gt CO2).

6.
Earth's Future ; 10(1), 2022.
Article in English | ProQuest Central | ID: covidwho-1655470

ABSTRACT

As the COVID‐19 virus spread over the world, governments restricted mobility to slow transmission. Public health measures had different intensities across European countries but all had significant impact on people's daily lives and economic activities, causing a drop of CO2 emissions of about 10% for the whole year 2020. Here, we analyze changes in natural gas use in the industry and gas distribution to the built environment during the first half of year 2020 with daily gas flows data from pipeline and storage facilities in Europe. We find that reductions of industrial gas use reflect decreases in industrial production across most countries. Surprisingly, natural gas use in the built environment also decreased despite most people being confined at home and cold spells in March 2020. Those reductions that we attribute to the impacts of COVID‐19 remain of comparable magnitude to previous variations induced by cold or warm climate anomalies in the cold season. We conclude that climate variations played a larger role than COVID‐19 induced stay‐home orders in natural gas consumption across Europe.

7.
Innovation (Camb) ; 3(1): 100182, 2022 Jan 25.
Article in English | MEDLINE | ID: covidwho-1592934

ABSTRACT

Precise and high-resolution carbon dioxide (CO2) emission data is of great importance in achieving carbon neutrality around the world. Here we present for the first time the near-real-time Global Gridded Daily CO2 Emissions Dataset (GRACED) from fossil fuel and cement production with a global spatial resolution of 0.1° by 0.1° and a temporal resolution of 1 day. Gridded fossil emissions are computed for different sectors based on the daily national CO2 emissions from near-real-time dataset (Carbon Monitor), the spatial patterns of point source emission dataset Global Energy Infrastructure Emissions Database (GID), Emission Database for Global Atmospheric Research (EDGAR), and spatiotemporal patters of satellite nitrogen dioxide (NO2) retrievals. Our study on the global CO2 emissions responds to the growing and urgent need for high-quality, fine-grained, near-real-time CO2 emissions estimates to support global emissions monitoring across various spatial scales. We show the spatial patterns of emission changes for power, industry, residential consumption, ground transportation, domestic and international aviation, and international shipping sectors from January 1, 2019, to December 31, 2020. This gives thorough insights into the relative contributions from each sector. Furthermore, it provides the most up-to-date and fine-grained overview of where and when fossil CO2 emissions have decreased and rebounded in response to emergencies (e.g., coronavirus disease 2019 [COVID-19]) and other disturbances of human activities of any previously published dataset. As the world recovers from the pandemic and decarbonizes its energy systems, regular updates of this dataset will enable policymakers to more closely monitor the effectiveness of climate and energy policies and quickly adapt.

8.
Proc Natl Acad Sci U S A ; 118(46)2021 11 16.
Article in English | MEDLINE | ID: covidwho-1510693

ABSTRACT

The COVID-19 global pandemic and associated government lockdowns dramatically altered human activity, providing a window into how changes in individual behavior, enacted en masse, impact atmospheric composition. The resulting reductions in anthropogenic activity represent an unprecedented event that yields a glimpse into a future where emissions to the atmosphere are reduced. Furthermore, the abrupt reduction in emissions during the lockdown periods led to clearly observable changes in atmospheric composition, which provide direct insight into feedbacks between the Earth system and human activity. While air pollutants and greenhouse gases share many common anthropogenic sources, there is a sharp difference in the response of their atmospheric concentrations to COVID-19 emissions changes, due in large part to their different lifetimes. Here, we discuss several key takeaways from modeling and observational studies. First, despite dramatic declines in mobility and associated vehicular emissions, the atmospheric growth rates of greenhouse gases were not slowed, in part due to decreased ocean uptake of CO2 and a likely increase in CH4 lifetime from reduced NO x emissions. Second, the response of O3 to decreased NO x emissions showed significant spatial and temporal variability, due to differing chemical regimes around the world. Finally, the overall response of atmospheric composition to emissions changes is heavily modulated by factors including carbon-cycle feedbacks to CH4 and CO2, background pollutant levels, the timing and location of emissions changes, and climate feedbacks on air quality, such as wildfires and the ozone climate penalty.


Subject(s)
Air Pollution , Atmosphere/chemistry , COVID-19/psychology , Greenhouse Gases , Models, Theoretical , COVID-19/epidemiology , Carbon Dioxide , Climate Change , Humans , Methane , Nitrogen Oxides , Ozone
9.
Sci Adv ; 7(45): eabf9415, 2021 Nov 05.
Article in English | MEDLINE | ID: covidwho-1501514

ABSTRACT

Activity reductions in early 2020 due to the coronavirus disease 2019 pandemic led to unprecedented decreases in carbon dioxide (CO2) emissions. Despite their record size, the resulting atmospheric signals are smaller than and obscured by climate variability in atmospheric transport and biospheric fluxes, notably that related to the 2019­2020 Indian Ocean Dipole. Monitoring CO2 anomalies and distinguishing human and climatic causes thus remain a new frontier in Earth system science. We show that the impact of short-term regional changes in fossil fuel emissions on CO2 concentrations was observable from space. Starting in February and continuing through May, column CO2 over many of the world's largest emitting regions was 0.14 to 0.62 parts per million less than expected in a pandemic-free scenario, consistent with reductions of 3 to 13% in annual global emissions. Current spaceborne technologies are therefore approaching levels of accuracy and precision needed to support climate mitigation strategies with future missions expected to meet those needs.

12.
Earth System Science Data Discussions ; : 1-31, 2021.
Article in English | Academic Search Complete | ID: covidwho-1241326

ABSTRACT

Tracking China's national and regional CO2 emission trends is becoming ever more crucial. The country recently pledged to achieve ambitious emissions reduction targets, however, high-resolution datasets for provincial level CO2 emissions in China are still lacking. This study provides daily CO2 emission datasets for China's 31 provinces, including for the first time, the province of Tibet. The inventory covers the emissions from three industrial sectors (power, industry and ground transport) during 2019 to 2020, with its temporal resolution at a daily level. In addition, the variations in CO2 emissions for seasonal, weekly and holiday periods have been uncovered at a provincial level for the first time. This new data was added to further analyze the impact that weekends and holidays have on China's CO2 emissions. Over weekend periods, carbon emissions are shown to reduce by around 3%. Spring Festival meanwhile, has the greatest impact on the reduction of China's CO2 emissions. This detailed and time-related inventory will facilitate a more local and adaptive management of China’s CO2 emissions during both the COVID-19 pandemic’s recovery and the ongoing energy transition. The data are archived at https://doi.org/10.5281/zenodo.4730175 (Cui et al., 2021). [ABSTRACT FROM AUTHOR] Copyright of Earth System Science Data Discussions is the property of Copernicus Gesellschaft mbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

14.
Geophys Res Lett ; 47(22): e2020GL090244, 2020 Nov 28.
Article in English | MEDLINE | ID: covidwho-989693

ABSTRACT

We use a global transport model and satellite retrievals of the carbon dioxide (CO2) column average to explore the impact of CO2 emissions reductions that occurred during the economic downturn at the start of the Covid-19 pandemic. The changes in the column averages are substantial in a few places of the model global grid, but the induced gradients are most often less than the random errors of the retrievals. The current necessity to restrict the quality-assured column retrievals to almost cloud-free areas appears to be a major obstacle in identifying changes in CO2 emissions. Indeed, large changes have occurred in the presence of clouds, and in places that were cloud free in 2020, the comparison with previous years is hampered by different cloud conditions during these years. We therefore recommend to favor all-weather CO2 monitoring systems, at least in situ, to support international efforts to reduce emissions.

15.
Emerg Microbes Infect ; 10(1): 66-80, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-979439

ABSTRACT

Coronaviruses (CoVs) are potential pandemic pathogens that can infect a variety of hosts and cause respiratory, enteric, hepatic and neurological diseases. Nonstructural protein 3 (nsp3), an essential component of the replication/transcription complex, is one of the most important antiviral targets. Here, we report the first crystal structure of multiple functional domains from porcine delta-coronavirus (PDCoV) nsp3, including the macro domain (Macro), ubiquitin-like domain 2 (Ubl2) and papain-like protease (PLpro) catalytic domain. In the asymmetric unit, two of the subunits form the head-to-tail homodimer with an interaction interface between Macro and PLpro. However, PDCoV Macro-Ubl2-PLpro mainly exists as a monomer in solution. Then, we conducted fluorescent resonance energy transfer-based protease assays and found that PDCoV PLpro can cleave a peptide by mimicking the cognate nsp2/nsp3 cleavage site in peptide substrates and exhibits deubiquitinating and de-interferon stimulated gene(deISGylating) activities by hydrolysing ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) and ISG15-AMC substrates. Moreover, the deletion of Macro or Macro-Ubl2 decreased the enzyme activity of PLpro, indicating that Macro and Ubl2 play important roles in maintaining the stability of the PLpro domain. Two active sites of PLpro, Cys260 and His398, were determined; unexpectedly, the conserved site Asp412 was not the third active site. Furthermore, the motif "NGYDT" (amino acids 409-413) was important for stabilizing the enzyme activity of PLpro, and the N409A mutant significantly decreased the enzyme activity of PLpro. These results provide novel insights into the replication mechanism of CoV and new clues for future drug design.


Subject(s)
Coronavirus Papain-Like Proteases/chemistry , Catalytic Domain , Coronavirus Papain-Like Proteases/physiology , Crystallization , HeLa Cells , Humans , Protein Domains , Protein Multimerization , Ubiquitination
16.
Friedlingstein, Pierre, O'Sullivan, Michael, Jones, Matthew W.; Andrew, Robbie M.; Hauck, Judith, Olsen, Are, Peters, Glen P.; Peters, Wouter, Pongratz, Julia, Sitch, Stephen, Corinne, Le Quéré, Canadell, Josep G.; Ciais, Philippe, Jackson, Robert B.; Alin, Simone, Luiz E O , C. Aragão, Arneth, Almut, Arora, Vivek, Bates, Nicholas R.; Becker, Meike, Benoit-Cattin, Alice, Bittig, Henry C.; Bopp, Laurent, Bultan, Selma, Chandra, Naveen, Chevallier, Frédéric, Chini, Louise P.; Evans, Wiley, Florentie, Liesbeth, Forster, Piers M.; Gasser, Thomas, Gehlen, Marion, Gilfillan, Dennis, Gkritzalis, Thanos, Luke, Gregor, Gruber, Nicolas, Harris, Ian, Hartung, Kerstin, Haverd, Vanessa, Houghton, Richard A.; Ilyina, Tatiana, Jain, Atul K.; Joetzjer, Emilie, Kadono, Koji, Kato, Etsushi, Kitidis, Vassilis, Korsbakken, Jan Ivar, Landschützer, Peter, Lefèvre, Nathalie, Lenton, Andrew, Lienert, Sebastian, Liu, Zhu, Lombardozzi, Danica, Marland, Gregg, Metzl, Nicolas, Munro, David R.; Julia E M , S. Nabel, Shin-Ichiro, Nakaoka, Niwa, Yosuke, O'Brien, Kevin, Ono, Tsuneo, Palmer, Paul I.; Pierrot, Denis, Poulter, Benjamin, Resplandy, Laure, Robertson, Eddy, Rödenbeck, Christian, Schwinger, Jörg, Séférian, Roland, Skjelvan, Ingunn, Smith, Adam J. P.; Sutton, Adrienne J.; Toste, Tanhua, Tans, Pieter P.; Tian, Hanqin, Tilbrook, Bronte, van der Werf, Guido, Vuichard, Nicolas, Walker, Anthony P.; Wanninkhof, Rik, Watson, Andrew J.; Willis, David, Wiltshire, Andrew J.; Yuan, Wenping, Xu, Yue, Zaehle, Sönke.
Earth System Science Data ; 12(4):3269-3340, 2020.
Article in English | ProQuest Central | ID: covidwho-971932

ABSTRACT

Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate – the “global carbon budget” – is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFOS) are based on energy statistics and cement production data, while emissions from land-use change (ELUC), mainly deforestation, are based on land use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) and terrestrial CO2 sink (SLAND) are estimated with global process models constrained by observations. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and understanding of the contemporary carbon cycle. All uncertainties are reported as ±1σ. For the last decade available (2010–2019), EFOS was 9.6 ± 0.5 GtC yr-1 excluding the cement carbonation sink (9.4 ± 0.5 GtC yr-1 when the cement carbonation sink is included), andELUC was 1.6 ± 0.7 GtC yr-1. For the same decade, GATM was 5.1 ± 0.02 GtC yr-1 (2.4 ± 0.01 ppm yr-1), SOCEAN 2.5 ± 0.6 GtC yr-1, and SLAND 3.4 ± 0.9 GtC yr-1, with a budget imbalance BIM of -0.1 GtC yr-1 indicating a near balance between estimated sources and sinks over the last decade. For the year 2019 alone, the growth in EFOS was only about 0.1 % with fossil emissions increasing to 9.9 ± 0.5 GtC yr-1 excluding the cement carbonation sink (9.7 ± 0.5 GtC yr-1 when cement carbonation sink is included), and ELUC was 1.8 ± 0.7 GtC yr-1, for total anthropogenic CO2 emissions of 11.5 ± 0.9 GtC yr-1 (42.2 ± 3.3 GtCO2). Also for 2019, GATM was 5.4 ± 0.2 GtC yr-1 (2.5 ± 0.1 ppm yr-1), SOCEAN was 2.6 ± 0.6 GtC yr-1, and SLAND was 3.1 ± 1.2 GtC yr-1, with a BIM of 0.3 GtC. The global atmospheric CO2 concentration reached 409.85 ± 0.1 ppm averaged over 2019. Preliminary data for 2020, accounting for the COVID-19-induced changes in emissions, suggest a decrease in EFOS relative to 2019 of about -7 % (median estimate) based on individual estimates from four studies of -6 %, -7 %,-7 % (-3 % to -11 %), and -13 %. Overall, the mean and trend in the components of the global carbon budget are consistently estimated over the period 1959–2019, but discrepancies of up to 1 GtC yr-1 persist for the representation of semi-decadal variability in CO2 fluxes. Comparison of estimates from diverse approaches and observations shows (1) no consensus in the mean and trend in land-use change emissions over the last decade, (2) a persistent low agreement between the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) an apparent discrepancy between the different methods for the ocean sink outside the tropics, particularly in the Southern Ocean. This living data update documents changes in the methods and data sets used in this new global carbon budget and the progress in understanding of the global carbon cycle compared with previous publications of this data set (Friedlingstein et al., 2019;Le Quéré et al., 2018b, a, 2016, 2015b, a, 2014, 2013). The data presented in this work are available at 10.18160/gcp-2020 (Friedlingstein et al., 2020).

17.
Nat Commun ; 11(1): 5172, 2020 10 14.
Article in English | MEDLINE | ID: covidwho-963670

ABSTRACT

The COVID-19 pandemic is impacting human activities, and in turn energy use and carbon dioxide (CO2) emissions. Here we present daily estimates of country-level CO2 emissions for different sectors based on near-real-time activity data. The key result is an abrupt 8.8% decrease in global CO2 emissions (-1551 Mt CO2) in the first half of 2020 compared to the same period in 2019. The magnitude of this decrease is larger than during previous economic downturns or World War II. The timing of emissions decreases corresponds to lockdown measures in each country. By July 1st, the pandemic's effects on global emissions diminished as lockdown restrictions relaxed and some economic activities restarted, especially in China and several European countries, but substantial differences persist between countries, with continuing emission declines in the U.S. where coronavirus cases are still increasing substantially.


Subject(s)
Air Pollutants/analysis , Carbon Dioxide/analysis , Coronavirus Infections/epidemiology , Pneumonia, Viral/epidemiology , Air Pollutants/economics , Betacoronavirus , COVID-19 , Carbon Dioxide/economics , Coronavirus Infections/economics , Coronavirus Infections/prevention & control , Environmental Monitoring , Fossil Fuels/analysis , Fossil Fuels/economics , Humans , Industry/economics , Nitrogen Dioxide/analysis , Nitrogen Dioxide/economics , Pandemics/economics , Pandemics/prevention & control , Pneumonia, Viral/economics , Pneumonia, Viral/prevention & control , SARS-CoV-2
18.
Sci Data ; 7(1): 392, 2020 11 09.
Article in English | MEDLINE | ID: covidwho-917543

ABSTRACT

We constructed a near-real-time daily CO2 emission dataset, the Carbon Monitor, to monitor the variations in CO2 emissions from fossil fuel combustion and cement production since January 1, 2019, at the national level, with near-global coverage on a daily basis and the potential to be frequently updated. Daily CO2 emissions are estimated from a diverse range of activity data, including the hourly to daily electrical power generation data of 31 countries, monthly production data and production indices of industry processes of 62 countries/regions, and daily mobility data and mobility indices for the ground transportation of 416 cities worldwide. Individual flight location data and monthly data were utilized for aviation and maritime transportation sector estimates. In addition, monthly fuel consumption data corrected for the daily air temperature of 206 countries were used to estimate the emissions from commercial and residential buildings. This Carbon Monitor dataset manifests the dynamic nature of CO2 emissions through daily, weekly and seasonal variations as influenced by workdays and holidays, as well as by the unfolding impacts of the COVID-19 pandemic. The Carbon Monitor near-real-time CO2 emission dataset shows a 8.8% decline in CO2 emissions globally from January 1st to June 30th in 2020 when compared with the same period in 2019 and detects a regrowth of CO2 emissions by late April, which is mainly attributed to the recovery of economic activities in China and a partial easing of lockdowns in other countries. This daily updated CO2 emission dataset could offer a range of opportunities for related scientific research and policy making.


Subject(s)
Carbon Dioxide/analysis , Construction Materials/analysis , Environmental Monitoring , Vehicle Emissions/analysis , COVID-19 , Coronavirus Infections , Pandemics , Pneumonia, Viral
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